Hox is in the hair: a break in colinearity?
نویسندگان
چکیده
منابع مشابه
Hox is in the hair: a break in colinearity?
During mammalian fetal development, axial structures acquire their specifications through the action of the Hox gene family of transcription factors (for review, see Krumlauf 1994). These are 39 such genes that are responsible for giving spatially restricted cues in a variety of embryonic derivatives, from the neural tube to the intestinal tract. In presomitic mesoderm, for example, level-speci...
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The Hox genes are involved in patterning along the A/P axes of animals. The clustered organization of Hox genes is conserved from nematodes to vertebrates. During evolution, the number of Hox genes within the ancestral complex increased, exemplified by the five-fold amplification of the AbdB-related genes, leading to a total number of thirteen paralogs. This was followed by successive duplicati...
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The relationship between the clustered organization of vertebrate Hox genes and their coordinate transcription in space and time is still lacking a convincing mechanistic explanation. Recent work on the regulatory interactions within Hox complexes suggests some reasons why these genes have remained clustered. Although these results do not address the puzzling issue of colinearity directly, they...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1998
ISSN: 0890-9369
DOI: 10.1101/gad.12.1.1